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Updated: Jan 14, 2026

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关于增强使用真实世界数据的随机试验的两步混合设计.

Jiapeng Xu1, Ruben P A van Eijk1,2, Alicia Ellis3

  • 1Department of Biomedical Data Science and Center for Innovative Study Design, Stanford University School of Medicine, California, CA.

Statistics in biopharmaceutical research
|October 23, 2025
PubMed
概括

混合临床试验使用现实世界数据 (RWD) 来增强随机试验,特别是对于罕见疾病. 新方法控制RWD和试验数据可交换时的I型错误率,提高试验有效性.

关键词:
肌缩性侧面硬化症 (AMLS) 是一种疾病.有条件的借款.混合临床试验 混合临床试验现实世界数据 (RWD) 随机对照临床试验测试-然后-池.一种类型I错误的错误.

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