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炎症,糖尿病脚和相关治疗

Yuqi Qin¹, Shan Deng²

¹Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in endocrinology

|October 23, 2025

概括

糖尿病足部炎症涉及NF-κB和介质蛋白,造成一个循环的损伤. 针对这些途径和使用生物标志物为个性化糖尿病足治疗提供了新的希望.

科学领域:

* 糖尿病足病理生理学和炎症机制.
* 糖尿病中NF-κB和互白素信号的分子生物学.

背景情况:

* 糖尿病足是一种糖尿病的严重并发症,涉及神经病变,缺血和炎症.
* 炎症微环境在糖尿病足的进展和组织损伤中起着关键作用.

研究的目的:

*系统地审查糖尿病足部的炎症调节网络,重点关注NF-κB和介质蛋白.
* 检查这些通路在组织损伤和Charcot脚发育中的作用.
* 评估糖尿病足的诊断生物标志物和新兴治疗策略.

主要方法:

* 对糖尿病足炎的科学文献进行系统审查.
* 信号通路的分析,包括AGE-RAGE,NF-κB,IL-6/RANKL.
* 评估炎症生物标志物 (PCT,hs-CRP,NLR) 和治疗干预措施.

主要成果:

*高血糖会激活AGE-RAGE轴,促进NF-κB信号传递和促炎循环.
*脚与IL-6/RANKL通路激活和神经信号受损有关.
*像PCT,hs-CRP和NLR这样的生物标志物显示出诊断效用.

结论:

* 糖尿病足部的炎症网络表现出时空异质性,这对于临床分层至关重要.
* NF-κB的向和将多omics数据与AI集成,显示了个性化糖尿病脚干预措施的前景.
*提供了新的见解,以解决糖尿病脚管理中的治疗挑战.

关键词:

通过NF-κB信号通路传递信号.糖尿病患者的糖尿病脚炎症性监管网络炎症性监管网络介质蛋白是介质蛋白家族中的一种.有针对性的治疗.

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