在T2DM下肢动脉疾病的T2DM中,血清CCL26和CCR3的变化和诊断值
Xuyan Zhang1, Ting Jia1, Li Li1
1Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
在患有2型糖尿病 (T2DM) 和下肢动脉疾病 (LEAD) 的患者中,化学激素CCL26 (CCL26) 和受体CCR3 (CCR3) 的血清水平升高. 这些生物标志物显示出在T2DM患者中诊断LEAD的潜力.
科学领域:
- 内分泌学和新陈代谢学
- 血管生物学 血管生物学
- 生物标志物发现发现
背景情况:
- 2型糖尿病 (T2DM) 是一个全球性的健康问题.
- 下肢动脉疾病 (LEAD) 是T2DM的一个常见并发症.
- 早期诊断和有效的T2DM与LEAD生物标志物至关重要.
研究的目的:
- 在有或没有LEAD的T2DM患者中检查化学CCL26 (CCL26) 和受体CCR3 (CCR3) 的血清水平.
- 评估CCL26和CCR3作为LEAD复杂的T2DM生物标志物的诊断潜力.
主要方法:
- 对197名T2DM患者 (157名T2DM,40名LEAD) 的回顾性研究.
- 测量了血清中的CCL26和CCR3水平.
- 进行了相关性,拉索和后勤回归分析.
- 用于评估预测功效的接收器操作特征 (ROC) 曲线分析.
主要成果:
- 领先组显示出更高的BMI,疾病持续时间,HbA1C,FINS和HOMA-IR (P<0.05).
- 在LEAD组中,血清中CCL26和CCR3水平显著升高 (P<0.05).
- CCL26和CCR3是正相关的 (r=0.337,P=0.034). 这两种类型的蛋白质具有正相关性.
- 对CCL26和CCR3的联合检测为预测LEAD的AUC为0.812的结果.
结论:
- 在LEAD的T2DM患者中,血清中CCL26和CCR3水平升高.
- CCL26和CCR3与T2DM中LEAD的发生密切相关.
- 对CCL26和CCR3的联合检测证明了T2DM中LEAD的显著预测价值.
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