基于草药的多组分无载体水凝具有通过调节MAPK和NF-κB信号通路而具有抗发烧和抗炎双重作用
Penglong Wang1, Xuemei Huang1, Shaohui Geng2
1School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, China.
Materials today. Bio
|October 23, 2025
概括
研究人员从传统中医药Ma-Xing-Shi-Gan (MXSGD) 中开发了一种新型的超分子水凝. 这种创新的水凝提供了增强的药物输送,并通过向炎症途径有效降低发烧.
科学领域:
- 药理学 药理学是指药理学的学科.
- 材料科学 材料科学 材料科学
- 传统中国医药 传统中国医药
背景情况:
- 传统草药 (THM) 配方为新药发现提供了丰富的来源.
- 来自植物的生物活性分子越来越多地用于开发治疗性超分子水凝.
- 马兴石甘 (MXSGD) 是一种经典的THM配方,用于治疗COVID-19症状和急性传染病.
研究的目的:
- 从MXSGD开发一种新的口服的超分子药物递送系统.
- 研究开发的超分子水凝的特性和治疗效果.
- 探索将THM与现代药物输送技术集成的潜力.
主要方法:
- 通过非共价相互作用将四个关键的MXSGD组件 (伪乙烯,杏仁素,糖酸,Ca2+) 联合组装成一个没有四级载体的超分子凝 (Quad hydrogel).
- 评估Quad水凝的物理特性,包括热可逆性,可注射性,机械强度和药物释放动力学.
- 评估Quad水凝在抑制脂聚糖 (LPS) 诱导的MAPK和NF-κB信号通路以及减轻大鼠发烧的体内功效.
主要成果:
- 开发的Quad水凝表现出优异的热可逆性,可注射性,机械强度,持续释放,肠内保留,增强药物吸收和生物相容性.
- 四方体水凝显著抑制了LPS诱导的MAPK和NF-κB信号通路.
- 夸德水凝协同缓解了老鼠的发烧,比原始的MXSG,伪胺单体和成分的物理混合物更有效.
结论:
- 这项研究提出了一种新的策略,用于开发基于经典THM配方的高级超分子药物.
- 开发的Quad水凝在治疗炎症和发烧方面具有显著的治疗潜力.
- 将THM与现代超分子化学相结合,为新药开发提供了一个有前途的途径.
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