出生时的社会知觉路径中的功能连接与四个月的面部注意力有关
Katarzyna Chawarska1, Angelina Vernetti1, Huili Sun2
1Child Study Center, Yale University School of Medicine, New Haven, Connecticut.
Biological psychiatry global open science
|October 23, 2025
概括
新生儿在正确的社会途径中的内在功能连接性预测了对面部的注意力,这是早期自闭症生物标志物. 这一途径对于识别自闭症中社会脆弱性的早期神经标志物至关重要.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 社会神经科学是一种社会神经科学.
背景情况:
- 右侧社会感知路径 (上角) 处理动态的面部线索,而腹部路径 (状回形) 处理静态的特征.
- 这些途径的早期发展及其与社会结果的联系在很大程度上是未知的.
- 自闭症谱系障碍 (ASD) 与社会沟通缺陷有关,强调需要了解早期神经发育.
研究的目的:
- 检查新生儿社会感知途径中的内在功能连接 (iFC).
- 调查新生儿iFC与4个月时对面部的注意力之间的关联,这是早期自闭症生物标志物.
- 探索新生儿iFC对后来的社会结果的预测价值.
主要方法:
- 在新生儿中测量了内在功能连接 (iFC),使用来自发展人类结合体项目 (dHCP) 和耶鲁队伍的静止状态fMRI.
- 在耶鲁新生儿的一个子组中,使用眼睛跟踪在4个月后评估了对面部的注意力.
- 在耶鲁大学的队列中考虑了自闭症的家族史.
主要成果:
- 所有检查的社会知觉路径都显示出显著的iFC,没有性别差异.
- 在有自闭症家族史的新生儿中,正确的社会途径中的联系与4个月时对面部的注意力有积极的相关性.
- 4个月时对面部的更多关注预测了18个月时更少的社会问题.
结论:
- 右侧社会感知路径是识别社会脆弱性的早期神经标志物的关键领域.
- 正确的社会途径中的新生儿iFC可以作为自闭症相关社会困难的早期预测标志物.
- 了解早期的功能连接对于为患有自闭症风险的个体制定及时干预措施至关重要.
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