睡眠轨迹和骨质疏松症发病率:来自两个前性队列研究的发现
Xiangxiang Zhang1, Zongshan Li2, Huanyong Tian3
1Shaoxing Seventh People's Hospital (Affiliated Mental Health Center, Medical College of Shaoxing University, Shaoxing, Zhejiang, China.
Frontiers in public health
|October 23, 2025
概括
持续不良睡眠质量显著提高了老年人骨质疏松症的风险. 改善睡眠可能是预防骨健康的关键策略.
科学领域:
- 老年学是一门学科.
- 睡眠医学 睡眠医学
- 骨健康研究 骨健康研究
背景情况:
- 大多数研究都在一个时间点评估睡眠质量,这限制了对其长期影响的理解.
- 纵向研究对于调查睡眠质量和健康结果的动态变化至关重要.
- 这项研究通过检查老年人睡眠质量轨迹来解决这一差距.
研究的目的:
- 为了研究老年人的睡眠质量模式随着时间的推移而发生的变化.
- 研究睡眠质量轨迹与骨质疏松症发病率之间的关系.
- 为了确定持续的睡眠质量不佳是否会增加骨质疏松症的风险.
主要方法:
- 分析了两个大型前性队列:英国老化纵向研究 (ELSA) 和美国健康与退休研究 (HRS).
- 使用标准化得分对睡眠质量进行量化,并确定睡眠质量轨迹 (持续,改善,恶化).
- 应用Cox比例危险回归模型来评估睡眠质量模式与骨质疏松症发病率之间的关联.
主要成果:
- 基线睡眠质量与ELSA和HRS队列中的骨质疏松症患病率显著相关.
- 与持续良好的睡眠者相比,持续睡眠质量差的个体患骨质疏松症的风险明显增加.
- 在两组数据中,特定危险比率 (HR) 表示风险增加 (ELSA:HR=1.89;HRS:HR=1.52).
结论:
- 睡眠质量差的轨迹与骨质疏松症的风险显著增加有关.
- 旨在改善睡眠质量的干预措施可以作为预防骨损失和骨质疏松症的潜在策略.
- 在两个主要队列中,一致的发现强调了睡眠在维持老龄化人口骨健康方面的重要性.
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