在HPV持久性和宫癌进展中的阴道微生物组
Jhommara Bautista1, Adriana Altamirano-Colina1, Andrés López-Cortés1
1Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador.
Frontiers in cellular and infection microbiology
|October 23, 2025
概括
阴道微生物组显著影响高风险的人类乳头瘤病毒 (HR-HPV) 持久性和宫癌的发展. 失生症预测疾病的进展,但恢复有益的细菌提供治疗潜力.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 持续高风险的人类乳头瘤病毒 (HR-HPV) 感染是导致宫癌的主要原因.
- 宫癌的进展受到宿主和环境因素的影响,包括阴道微生物群.
- 阴道微生物组从*Lactobacillus crispatus*主导转变为失生状态 (例如, *Gardnerella*, *Fannyhessea*, *Sneathia*) 与HPV持久性和炎症有关.
研究的目的:
- 研究阴道微生物组在调节HR-HPV持久性和宫癌发生方面的作用.
- 评估特定微生物社区状态类型 (CST) 作为宫癌风险生物标志物的潜力.
- 探索阴道微生物组调制对宫癌预防的治疗影响.
主要方法:
- 对宫-阴道微生物组合的分析及其与HR-HPV感染状况的相关性.
- 评估特定微生物群落 (CST IV) 与子宫病变进展之间的关联.
- 评估失生症对粘膜免疫和宿主/病毒表观遗传学的影响.
主要成果:
- 社区国家类型IV (CST IV) 微生物群强烈预测持续的HR-HPV感染和进展到高度宫病变.
- 宫性阴道失生症改变了粘膜免疫力,促进了表观遗传变化,促进了病毒免疫逃避和瘤发生.
- 恢复 * Lactobacillus * 主导地位显示出改善HPV疫苗疗效和减少子宫癌的希望.
结论:
- 阴道微生物组是HPV驱动的宫癌发生的积极决定因素,而不是被动旁观者.
- 阴道微生物组分析,特别是CST IV,为宫癌的非侵入性风险分层提供了潜力.
- 与益生菌一样,针对微生物组的干预措施是预防和治疗宫癌的有希望的策略.
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