一个线索来澄清Omicron的起源
Fernando Martinez-Hernandez1, Claudia Irais Muñoz-Garcia2, Emilio Rendon-Franco2
1Hospital General Dr Manuel Gea Gonzalez, Ciudad de Mexico, Mexico.
Royal Society open science
|October 23, 2025
概括
2020年底,在墨西哥城的城市动物中检测到Omicron变种,这表明其潜在的动物起源或在正式出现之前的无声传播. 这一发现突显了同类动物动物在SARS-CoV-2进化中的作用.
科学领域:
- 病毒学 病毒学
- 动物传播疾病 动物传播疾病
- 分子流行病学分子流行病学
背景情况:
- 同人类的动物可以作为各种病原体的储.
- 了解SARS-CoV-2传播动态,包括潜在的动物储库,对于公共卫生至关重要.
- 之前的研究已经探索了病毒性疾病的动物性起源.
研究的目的:
- 来自墨西哥城的同类动物动物中识别SARS-CoV-2变种.
- 调查动物在SARS-CoV-2 Omicron变种的出现和演变中的潜在作用.
- 为了探索关于Omicron变异的起源的假设.
主要方法:
- 从动物 (Mus musculus,Rattus norvegicus) 的便样本的采集和分子分析.
- 使用分子类型化技术识别病毒变体.
- 通过参考中心和GISAID分析确认变种存在.
主要成果:
- 在老鼠和小鼠中分别发现了BA.5.2和BA.5.1.17的Omicron变体.
- 在动物中存在Omicron变异被参考中心和GISAID证实.
- 动物Omicron的检测时间早于其正式出现,这表明自2020年底以来的流通.
结论:
- 城市动物可能在SARS-CoV-2 Omicron变种的早期循环和进化中发挥了作用.
- "无声传播"和潜在的"老鼠起源"的组合可以解释Omicron的出现.
- 调查结果表明,Omicron在正式出现前一年就存在于城市动物中,并在墨西哥首次COVID-19浪潮期间放大.
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