空气污染,MIND饮食,神经退行性疾病的风险在不同的衰老状态
Jin Zhang1, Tiantian Gu1, Jianbo Jin1
1Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
Environment & health (Washington, D.C.)
|October 23, 2025
概括
地中海-DASH干预神经退行性延迟 (MIND) 饮食可以预防与空气污染相关的神经退行性疾病 (NDD). 这种益处在端粒长度较短的个体中更为明显,这表明在减轻与衰老相关的风险方面可能发挥作用.
科学领域:
- 环境健康 环境健康
- 营养神经科学 营养神经科学
- 流行病学 流行病学
背景情况:
- 空气污染对神经退行性疾病 (NDD) 风险的担忧越来越大.
- 地中海-DASH干预神经退行性延迟 (MIND) 饮食是一种潜在的保护性饮食模式.
- 空气污染,饮食和NDD风险之间的相互作用,特别是考虑到诸如端粒长度等衰老标志物,仍未得到充分研究.
研究的目的:
- 调查空气污染暴露和MIND饮食对NDD发展风险的综合和修改影响.
- 将这些影响与端粒长度 (RTL) 作为生物衰老标志物的关系进行研究.
- 确定MIND饮食是否可以减轻与特定空气污染物相关的NDD风险.
主要方法:
- 一项使用英国生物库数据的11年前性队列研究 (N=115,467).
- 采用了时间变化的Cox比例危险回归模型.
- 暴露评估包括颗粒物 (PM2.5,PM10),二氧化 (NO2),氧化 (NOx) 和它们的主要成分 (PC1).
- 计算和分析了MIND饮食得分,以确定其与空气污染物的相互作用.
主要成果:
- 所有评估的空气污染物都与短期和长期RTL子组中NDD风险增加有显著的关联.
- 较高的MIND饮食得分与空气污染暴露的背景下NDD风险降低有关.
- 这种MIND饮食的保护作用在短RTL亚组中尤为明显,这表明在生物衰老较晚的个体中 (P-相互作用值<0.083) 有更强的益处.
结论:
- 在减少因空气污染暴露而导致的神经退行性疾病 (NDD) 的风险方面,MIND饮食可能发挥着至关重要的作用.
- 端粒长度较短的个体 (加速衰老的标志物) 可能特别受益于坚持MIND饮食,以抵消与空气污染相关的NDD风险.
- 这些发现强调了像MIND饮食这样的饮食干预措施在旨在减轻环境暴露的神经后果的公共卫生战略中的重要性.
相关概念视频
Aging
587
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
587
Alzheimer's Disease: Overview
1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
Psychoneuroimmunology: Diabetes and Cancer
437
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
437
Dementia
515
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
515
Cognitive Development During Adulthood
770
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
770
The Effect of Aging on Tissues
3.3K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.3K


