在体外受精之前人类精子的微塑性污染需要注意早期生命暴露风险
Yu Su1,2, Chenqi Yang1,3, Hong Liao4
1Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Environment & health (Washington, D.C.)
|October 23, 2025
概括
塑料制品中的微塑料 (MP) 在辅助生殖技术 (ART) 期间污染了人类精子. 这项研究证实了对国会议员的直接精子暴露,突出了ART怀孕婴儿的风险.
科学领域:
- 生殖生物学 生殖生物学
- 材料科学 材料科学 材料科学
- 环境健康 环境健康
背景情况:
- 不孕率的上升增加了对辅助生殖技术 (ART) 的需求.
- 医疗塑料用品对于ART至关重要,但可能会释放微塑料 (MPs).
- 在ART手术过程中人类生殖细胞的潜在MP污染是一个重大问题.
研究的目的:
- 为了调查人类精子在ART期间从塑料器皿中释放的微塑料 (MPs) 的直接暴露.
- 在精子样本中识别和可视化MP,并评估其来源和数量.
- 评估与MP暴露在ART中相关的健康风险.
主要方法:
- 利用光学光热红外成像来识别精子样本中的10μm以下聚乙烯 (PS) MPs.
- 分析了由机械损伤 (划伤) 对PS塑料培养皿产生的MP.
- 基于划痕尺寸和表面损伤的量化MP生成.
主要成果:
- 在机械提取的精子样本中确认了聚烯MPs与蛋白质冠状的存在.
- 由工具诱导的聚合物切割和残留树脂颗粒产生的已识别的MP.
- 量化每次划痕的MP生成 (2.013MP) 和估计的暴露剂量 (10022,000颗粒/毫升).
- 证明了41.781.5%的从划伤中产生的MP被用精子细胞检索出来.
结论:
- 提供了可靠的证据,证明在ART过程中人类精子直接暴露在MP中.
- 建议在ART中减少塑料用品的使用,以减轻婴儿的潜在健康风险.
- 强调需要进一步研究MP暴露对生殖健康的长期影响.
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