在COSMOS试验中的随机样本中对血清TMAO和胆进行试点和可行性分析
Irene Sánchez Gavilán1,2, Sidong Li1, Michael G Sweet3
1Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. hsesso@bwh.harvard.edu.
Food & function
|October 23, 2025
概括
在一项试点研究中,可可提取物 (CE) 补充剂没有显著改变三甲基胺N氧化物 (TMAO) 或胆水平. 需要进行更大规模的试验来确认CE是否会影响这些心血管疾病生物标志物.
科学领域:
- 心血管健康 心血管健康
- 营养生物化学 营养生物化学
- 代谢学 代谢学 代谢学
背景情况:
- 三甲基胺N氧化物 (TMAO) 是一种与心血管疾病 (CVD) 相关的饮食生物标志物.
- 胆是一种必需的营养素,在细胞结构和肝脏健康方面发挥作用.
- 有限的人类数据存在可可提取物 (CE) 对TMAO和胆水平的影响.
研究的目的:
- 评估每日可可提取物 (CE) 补充剂对1年血清TMAO和胆水平变化的影响.
- 为了为未来的样本大小计算提供信息,在COSMOS试验中进行更大的分析.
- 探索与CE分配有关的TMAO和胆轨迹.
主要方法:
- 在COSMOS随机对照试验中的试点研究 (n=37).
- 血TMAO和胆测量使用液态色谱与双重质谱.
- 线性混合效应模型分析了TMAO和胆调整对共变量的变化.
主要成果:
- 在CE和安慰剂组之间,TMAO (P=0.62) 或胆 (P=0.21) 的1年变化没有统计学上显著的差异.
- 趋势表明,CE组的TMAO含量较低,胆含量较高,但置信区间较宽.
- 试点数据表明,需要1500名参与者来检测TMAO中的1.5μM差异.
结论:
- 在这项试点研究中,每天补充CE对TMAO或胆水平在1年内没有统计学上显著的影响.
- 样本规模有限限制了检测重大变化的能力.
- 需要对更大的队列进行进一步的研究,以阐明CE在调节TMAO和胆代谢中的作用及其潜在的心血管益处.
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