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女性腹部肥胖症的神经网络失调:不同食欲亚型的独特功能连接
Qifu Li1,2, Siwen Zhao1,2, Gaoyangzi Huang1,2
1Yunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment, Yunnan University of Chinese Medicine, Kunming, China.
Obesity (Silver Spring, Md.)
|October 23, 2025
概括
腹部肥胖女性的食欲差异与不同的大脑活动模式有关. 强食欲亚型在自我调节网络中的连接性降低,而适度食欲亚型在网络之间的连接性改变.
科学领域:
- 神经科学是一个神经科学.
- 肥胖问题研究研究
- 脑部成像 脑部成像
背景情况:
- 食欲失调是肥胖的一个关键因素.
- 了解食欲亚型的神经支对于有针对性的干预至关重要.
- 腹部肥胖 (AO) 与代谢和神经功能的改变有关.
研究的目的:
- 在女性受试者中研究食欲调节障碍的神经机制.
- 在AO中确定中度食欲 (MA) 和强食欲 (SA) 亚型之间的功能连接 (FC) 和网络差异.
- 将AO亚型中的大脑网络模式与健康对照 (HC) 进行比较.
主要方法:
- 在休息状态功能磁共振成像 (fMRI) 中,对60名女性进行了AO (30MA,30SA) 和30名HC.
- 独立组件分析 (ICA) 用于分析FC内部和静止状态网络之间的功能网络连接 (FNC).
- 评估了网络变化与肥胖相关指标的相关性,如BMI和食欲VAS得分.
主要成果:
- 与HC相比,AO两种亚型在默认模式网络 (DMN) 和视觉网络 (VN) 中都显示了较低的FC.
- 与MA相比,SA在前面对面网络 (FPN) 和下角回形FC中表现出进一步降低的FC.
- MA显示DMN左侧FPN (FPN_L) FNC增加,而SA在FPN和VN中显示FC和肥胖指标之间的负相关性.
结论:
- 独特的大脑网络模式标志着AO的食欲亚型.
- SA的FC降低了自我调节和视觉处理网络,可能会导致食欲失调.
- MA的DMN-FPN_L FNC增加可能表明适应性互联网互动,与SA的模式形成鲜明对比.
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