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一升聚乙烯甘醇与 Askorbic 酸提供可比清洁质量为两升的治疗方案在肠道准备不活跃的性结肠炎患者 - 一个随机的,多中心,单盲试验
Ji Min Lee1, Kang-Moon Lee2, Sung Jae Shin3
1Internal Medicine, The Catholic University of Korea College of Medicine.
一升聚乙烯甘醇与酸 (PEG+Asc) 有效治疗性结肠炎 (UC) 肠道准备. 这种低体积的选择是安全的,耐受性很好,为静止UC患者提供了可行的替代方案.
科学领域:
- 胃肠病学 胃肠病学
- 临床试验 临床试验
- 患者护理 患者护理
背景情况:
- 对性结肠炎 (UC) 的以患者为中心的护理需要尽量减少结肠镜检查负担,特别是肠道准备.
- 越来越多地使用低容量肠道制剂,但UC患者1升聚乙烯甘醇与酸 (PEG+Asc) 的数据有限.
研究的目的:
- 为了比较1-L与2-L PEG+Asc在静止UC患者的结肠镜检查中的疗效,安全性和可接受性.
- 评估PEG+Asc作为UC患者的低体积肠道制备选项.
主要方法:
- 一个多中心的,随机的,单盲的,非劣等性研究,涉及成年门诊患者与稳定的UC.
- 通过波士顿肠道准备量表评估肠道清洁;使用顺序量表评估患者接受度和耐受度.
- 根据疾病活动和实验室数据评估的安全性.
主要成果:
- 在每条协议分析中,成功清除的98.6% (1-L) 和97.1% (2-L),达到非劣等性.
- 总体耐受性和可接受性相似;恶心更频繁与1-L PEG+Asc.
- 在1-L组中,轻微的,临床上无意义的电解质转移更常发生.
结论:
- 一升的PEG+Asc是休眠UC患者的有效和安全的肠道制剂.
- 它为2-L疗法提供了一个可行的低容量替代方案.
- 考虑对老年人或并发症患者进行仔细的患者选择和监测.
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