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在与慢性高风险人类乳头瘤病毒感染相关的人类癌症中的血管仿真

Euclides Avila¹, Edgar Armando Méndez-Pérez¹, Lorenza Díaz¹

¹Departamento de Biología de la Reproducción Dr. Carlos Gual Castro, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Future oncology (London, England)

|October 23, 2025

概括

在与人类乳头瘤病毒 (HPV) 相关的癌症中探索了血管仿真 (VM). 了解VM的分子调节器可能会导致针对瘤细胞信号通路的新型癌症疗法.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

血管仿真 (VM) 描述了瘤细胞形成血管状通道,有助于癌症的进展和治疗耐药性.
高风险的人类乳头瘤病毒 (HPV) 类型16和18与各种癌症有关,包括宫癌和头癌.
虽然在宫癌和口腔状细胞癌 (OSCC) 中已知VM,但其在其他HPV相关恶性瘤中的作用尚未得到充分研究.

研究的目的:

本综述综合了HPV相关癌症的背景下关于血管生成模仿的当前文献.
这项研究旨在阐明驱动VM在这些特定癌症类型中的机制和分子调节剂.
识别这些调节剂可能会揭示HPV相关癌症的新疗法标.

主要方法:

使用PubMed和谷歌学者进行了一项文献审查.
搜索集中在2024年10月至2025年4月期间发表的研究.
该综述分析了宫癌和OSCC中VM的机制和分子调节剂,并推断到与HPV相关的其他癌症.

主要成果:

常见的VM机制包括表皮层-介质酶过渡,缺氧和STAT3和PI3K/AKT通路的激活.
在宫癌中确定的特定分子调节剂包括TXNDC5,CHI3L1,红素,miR-124和miR-29b.
在OSCC中,强调了诸如原XVI,LGR5,ALDH1,Beclin 1,VE-cadherin,CD44,HIF-1α和SOX7等调节剂.

结论:

在与HPV相关的癌症中阐明VM的分子基础对于推进治疗策略至关重要.
准特定的信号通路和已识别的分子调节器是一个有希望的翻译方法.
对所有与HPV相关的癌症中VM作用的进一步研究可能会揭示更广泛的治疗机会.

关键词:

血管生成的模仿.血管新生是因为血管新生.宫癌:子宫癌是一种癌症.头部和部状细胞癌瘤人类乳头瘤病毒人类乳头瘤病毒

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