基于知识的临床毒理学顾问对诊断单次暴露的外部验证
Hugo Lerogeron1,2, Joel Schipper3, Jay Schauben4
1Université Claude Bernard Lyon1, LBBE, UMR 5558, CNRS, Villeurbanne, France.
Clinical toxicology (Philadelphia, Pa.)
|October 23, 2025
概括
这项研究使用来自法国的数据对毒理学诊断模型进行了外部验证,达到75.4%的准确性. 该模型有望改善中毒的临床决策,尽管需要在不同人群中进一步验证.
科学领域:
- 毒理学 毒理学 毒理学
- 临床信息学 临床信息学
- 医疗决策支持 医疗决策支持
背景情况:
- 临床预测模型有助于诊断,但往往缺乏外部验证,限制了它们在现实世界中的实用性.
- 基于知识的系统在毒理学中很有价值,因为需要快速诊断和稀缺的专业知识.
- 来自佛罗里达州的一个有前途的诊断模型需要外部验证来评估其通用性.
研究的目的:
- 为外部验证佛罗里达州开发的毒理学临床预测模型.
- 评估模型的通用性,使用来自法国里昂毒素信息中心的数据.
- 评估模型在不同的语言和医疗保健系统环境中的表现.
主要方法:
- 来自法国里昂602例中毒病例的匿名临床数据被用于外部验证.
- 法语的症状和物质描述被标准化并翻译成英语.
- 数据被映射到原来的佛罗里达州模型的参数,并使用Top-K精度评估性能.
主要成果:
- 该模型在所有验证病例中实现了75.4%的总体Top-10%准确率.
- 严重病例 (87.0%) 的精度最高,致命病例 (57.6%) 的精度最低.
- 外部验证结果与内部验证指标相当,在某些情况下甚至超过.
结论:
- 毒理学诊断系统尽管面临跨语言和数据库挑战,但仍表现出强大的准确性,支持其临床适用性.
- 为了更广泛的采用,在不同人群中进一步的国际验证至关重要.
- 整合更多患者数据的精细模型可以显著提高全球毒理学诊断.
更多相关视频
08:25Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure
Published on: June 5, 2020
7.2K
17:28Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
Published on: June 17, 2015
13.1K
相关概念视频
01:26Toxic Reactions: Overview
1.8K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.8K
01:36Types of Toxins
3.1K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
3.1K
01:25Mutagenicity and Carcinogenicity
1.9K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.9K
01:15Data Validation
572
Method validation is a crucial process in analytical chemistry designed to confirm that a given method consistently produces reliable and high-quality results. This process is essential when a method is applied to different sample matrices or when procedural modifications are made, ensuring that the results meet acceptable standards across various applications.
Key parameters for method validation include:
Key parameters for method validation include:
572
01:03Data Validation
6.3K
Data validation is an essential part of a comprehensive assessment. Validation is confirming or verifying and opening the door to gathering more assessment data as it clarifies vague or unclear data. The process of checking and verifying the collected information is called data validation. The primary purpose of data validation is to ensure data is as free from error, bias, and misinterpretation as possible.
Nursing assessment guides are generally based on holistic models rather than medical...
Nursing assessment guides are generally based on holistic models rather than medical...
6.3K
01:19Pharmacovigilance
1.6K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.6K