患有心力衰竭的八代人患者的患者特征和死亡率趋势:现实世界的分析
Caroline Hartwell Garred1, Mariam Elmegaard1, Daniel Mølager Christensen2
1Department of Cardiology, Herlev and Gentofte University Hospital, Copenhagen, Denmark.
JACC. Advances
|October 23, 2025
概括
最近的心力衰竭 (HF) 的进展改善了八十岁人的生存率. 尽管出现了更多的并发症,但新发性HF的老年患者的2年死亡风险在20年内显著下降.
科学领域:
- 老年学是一门学科.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 关于最近心力衰竭 (HF) 管理进展对非常老年人群的生存率的影响存在不确定性.
- 研究老年心力衰竭患者的生存趋势对于公共卫生倡议至关重要.
研究的目的:
- 分析新发性心力衰竭 (HF) 诊断的丹麦80岁以上人群中2年死亡率的20年趋势.
- 为了确定与死亡率的变化相关的因素在这个人口在二十年的变化.
主要方法:
- 在2002年至2021年期间,全国范围内对80岁及以上的丹麦患者进行了一项队列研究,这些患者在2002年至2021年期间患有发生性HF.
- 评估2年死亡率的总体和子组 (年龄,性别,虚弱,并发症).
- 随着时间的推移,评估基于证据的HF疗法,包括ACE抑制剂,ARB,RNAI,β-阻断剂和MRA.
主要成果:
- 在2002-2006年至2017-2021年期间,八十岁的八十岁人群中,发生过HF的原始2年死亡风险下降了8%.
- 经过调整后的分析显示,晚期死亡风险降低了28%.
- 所有子组的死亡率有所改善,门诊诊断增加,随着时间的推移记录了更多的并发症.
结论:
- 八十多岁的心力衰竭患者的两年死亡率在过去二十年中有所改善.
- 在这个老年人群中,尽管在诊断HF时记录的并发症增加,但仍观察到这些改善.
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