超蛋白通过调节炎症和氧化应激减轻素诱导的急性胰腺炎
İhsan Karaboğa1, Hamza Malik Okuyan2, Fatin Rüştü Polat3
1Department of Histology and Embryology, Faculty of Medicine, Kırklareli University, Kırklareli, Turkey. ihsankaraboga@gmail.com.
Journal of molecular histology
|October 23, 2025
概括
超素 (HP) 显示出显著的抗炎和抗氧化作用,在大鼠模型中防止急性胰腺炎 (AP). 这种天然的黄胺可能为辅助AP治疗提供了希望.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 病理学 病理学 病理学
背景情况:
- 急性胰腺炎 (AP) 是一种严重的炎症状况,其特征是腹痛,恶心和吐.
- 过素 (HP),一种天然的黄类化合物,表现出已知的抗氧化和抗炎性质,但其在AP中的作用尚不清楚.
研究的目的:
- 在大鼠模型中研究Hyperin (HP) 对素诱导的急性胰腺炎 (AP) 的保护作用.
- 评估HP对胰腺组织病理学,炎症性细胞因子和氧化应激标志物的影响.
主要方法:
- 一个AP大鼠模型被诱导使用素注射.
- 胰腺组织被通过组织病理学评估 (血素-色素染色).
- 测量了NF-κB和TNF-α的表达,氧化应激标志物 (MDA,SOD,CAT,GPx),血清氨酶/脂酶和细胞因子 (IL-6,IL-10) 的表达.
主要成果:
- 惠普治疗显著减少了胰腺组织学损伤 (胀,亡,真空化).
- HP显著降低了NF-κB和TNF-α的表达,减弱了氧化应激 (恢复了SOD,减少了MDA) 和调节的细胞因子水平 (降低了IL-6,增加了IL-10).
- 惠普显著降低了血清粉酶和脂酶水平.
结论:
- 超蛋白 (HP) 在素诱导的AP大鼠模型中具有显著的抗炎和抗氧化作用.
- 惠普的保护机制包括抑制NF-κB和TNF-α通路以及激活SOD.
- 这些发现表明,Hyperin (HP) 具有作为急性胰腺炎自然辅助疗法的潜力.
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