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多发性骨髓瘤患者与最小残留疾病的坦德姆自身干细胞移植:一个探索性研究

Sieun Oh¹, Sung-Soo Park^2,3,4, Jung Yeon Lee^1,5,6

¹Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

|October 23, 2025

概括

串联自主干细胞移植 (tASCT) 有利于多发性骨髓瘤 (MM) 患者的最小残留疾病 (MRD). 在tASCT后实现显著的MRD降低改善了无进展生存率,支持其在MRD阳性MM中使用.

科学领域:

血液学血液学血液学
在瘤学瘤学.
干细胞移植干细胞移植

背景情况:

多发性骨髓瘤 (MM) 是一种血液性恶性瘤.
最小残留疾病 (MRD) 是MM的关键预后因素.
串联自主干细胞移植 (tASCT) 是高风险MM的治疗选择.

研究的目的:

评估tASCT对MM患者MRD动态的影响.
评估tASCT对MRD反应和临床结果之间的关系.

主要方法:

对28名接受tASCT的MM患者的回顾性分析.
分层分为广泛的 (≥50%的减少) 和适度的 (<50%的减少) MRD 清除组.
各组之间MRD水平和生存结果的比较.

主要成果:

在tASCT后,整体MRD下降了 (0.111%至0.056%).
广泛清除组显示显著的MRD减少和更长的无进展生存时间 (37.7vs16.3个月).
适度清除组经历了MRD的增加.

结论:

tASCT为MRD阳性MM患者提供临床益处.
在tASCT后显著减少MRD与改善PFS有关.
在初始ASCT后,tASCT是MRD阳性MM患者的可行方法.

关键词:

最少残留疾病的最小残留疾病.多发性骨髓瘤是一种多发性骨髓瘤.坦德姆自主干细胞移植手术

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