血清维生素D与中国肥胖人口的健康状况之间的性别特定关联:一个跨部分研究
Jiahui Yu1, Huawu Yang1, Dafang Zhan1
1Center of Gastrointestinal and Minimally Invasive Surgery, Department of General Surgery, The Third People's Hospital of Chengdu, Chengdu, Sichuan Province, China.
Obesity surgery
|October 23, 2025
概括
较低的维生素D水平与不健康的肥胖有关,影响代谢健康和身体组成. 保持足够的VD可能对肥胖个体的代谢健康至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 营养科学 营养科学
背景情况:
- 新出现的证据表明,血清维生素D (VD) 水平与肥胖的代谢概况之间存在联系.
- 了解这种关系对于管理与肥胖有关的健康问题至关重要.
研究的目的:
- 研究肥胖个体中静脉疾病水平,代谢健康和身体组成之间的关系.
- 探索这些关联中的潜在的性别特异差异.
- 根据静脉疾病水平和代谢指标识别肥胖的亚型.
主要方法:
- 线性回归分析以评估静脉疾病与健康指标的关联.
- 共识聚类算法 (CCA) 用于识别男性和女性的肥胖亚型.
- 限制立方线 (RCS) 模型用于剂量反应分析.
- 调解分析,以探索代谢指标的作用.
主要成果:
- 在男性中发现了静脉疾病和空腹血糖,HbA1c,甘油三和HOMA-IR之间的反向关系.
- 在女性中观察到VD和HDL-C之间的积极关联.
- 确定了两种肥胖亚型:"不健康"和"相对健康".
- 较高的VD水平 (男性≥37.7μmol/mL,女性≥30.0μmol/mL) 与"相对健康"的肥胖相关.
- 在男性中,HOMA-IR介导了静脉疾病的31%;在女性中,HDL-C介导了15.8%.
结论:
- 血清静脉疾病水平较低的肥胖个体表现出较差的代谢健康和身体成分.
- 静脉疾病状态是区分肥胖亚型的一个重要因素.
- 向静脉疾病水平可能是改善肥胖人口代谢健康的策略.
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