Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Glaucoma: Overview01:25

Glaucoma: Overview

1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.2K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

708
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
708
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

958
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
958
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.1K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.1K
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

10.0K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
10.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Extracting patient reported cannabis use and reasons for use from electronic health records: a benchmarking study of large language models.

medRxiv : the preprint server for health sciences·2026
Same author

Effects of baclofen and lorazepam on interhemispheric inhibition in humans.

Experimental physiology·2026
Same author

Incidence of cutaneous lupus erythematosus and systemic progression: A Nationwide study in Korea.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

Prevalence of asymmetric hearing loss in Korean adults.

Acta oto-laryngologica·2026
Same author

Incidence and risk factors of first-ever diabetic foot ulcers in patients with newly diagnosed type 2 diabetes mellitus.

Diabetes research and clinical practice·2026
Same author

High-fat overfeeding is associated with tissue-specific liver-adipose immunometabolic remodeling in rainbow trout.

Fish & shellfish immunology·2026

相关实验视频

Updated: Jan 14, 2026

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System
07:04

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Published on: February 4, 2021

2.4K

与黄斑病相关的系统性药物

Jiyeong Kim1, Seong Joon Ahn2, Jiyeon Park3

  • 1Department of Pre-Medicine, College of Medicine, and Biostatistics Laboratory, Medical Research Collaborating Center, Hanyang University, Seoul, Republic of Korea.

JAMA ophthalmology
|October 23, 2025
PubMed
概括
此摘要是机器生成的。

这项研究确定了五种系统性药物,包括阿皮克萨班,帕克利塔塞尔,易布鲁替尼和西尔德纳菲尔,与黄斑病变有关. 结合药物监测和健康声明数据,提供了一种可靠的方法来检测药物诱导的黄斑毒性.

更多相关视频

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
05:14

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

1.5K
Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

4.1K

相关实验视频

Last Updated: Jan 14, 2026

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System
07:04

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Published on: February 4, 2021

2.4K
Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
05:14

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

1.5K
Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

4.1K

科学领域:

  • 眼科医生 眼科 眼科
  • 药物监督 药物监督 药物监督
  • 药品安全 药品安全

背景情况:

  • 系统性药物可能会导致未被识别的黄斑毒性,需要早期识别以保护视力.
  • 鉴定具有潜在黄斑不良影响的药物对于患者安全至关重要.

研究的目的:

  • 使用药物监测数据识别可能与黄斑病相关的全身药物.
  • 在一个大规模的人口数据库中评估已识别的药物的黄斑不良影响.

主要方法:

  • 这是一项两部分研究,涉及FAERS (食品和药物管理局不良事件报告系统) 数据的不成比例性分析,用于信号识别.
  • 一项基于人口的队列研究,使用韩国医疗保险审查和评估服务 (HIRA) 数据库来评估协会.

主要成果:

  • 在FAERS中,五种系统性药物 (fingolimod,apixaban,paclitaxel,ibrutinib,sildenafil) 被确定为潜在的黄斑病症信号.
  • 在HIRA数据库中,观察到阿皮克萨班 (3.08),帕克利塔克塞尔 (2.85),易布鲁替尼 (3.71) 和西尔德纳菲尔 (2.75) 的发生率增加.
  • 对于帕克利塔塞尔和易布鲁替尼,观察到剂量反应关系,这表明暴露水平较高的风险增加.

结论:

  • 药物监测和健康声明分析的综合方法成功地确定了巨病与几种全身药物之间的关联.
  • 这种综合方法提供了一种具有成本效益和强大的策略,用于检测具有潜在未被认可的黄斑不良影响的全身药物.