夜间暴露于光线和心血管疾病发生率
Daniel P Windred1, Angus C Burns2,3,4,5, Martin K Rutter6,7
1Flinders Health and Medical Research Institute (Sleep Health), Flinders University, Bedford Park, South Australia, Australia.
JAMA network open
|October 23, 2025
概括
暴露在夜间的光线显著增加了心血管疾病的风险,包括心脏病发作和中风. 减少夜间光线暴露可能是预防心血管疾病的关键策略.
科学领域:
- 心血管流行病学心血管流行病学
- 时间生物学 时间生物学
- 环境健康 环境健康
背景情况:
- 由于夜间的光线引起的循环节障碍是已知的心血管风险因素.
- 光照模式与心血管疾病发病率之间的准确关系需要进一步阐明.
研究的目的:
- 调查日夜照明暴露与心血管疾病发病率之间的关联.
- 为了确定遗传易感性,性别或年龄是否会改变暴露于光线和心血管疾病之间的联系.
主要方法:
- 一项前性队列研究,利用英国生物库数据从88905名参与者超过9.5年.
- 客观的光照暴露数据通过手腕穿戴的光传感器收集,每位参与者一个星期.
- 来自英国国家卫生服务记录的心血管疾病发病率,使用Cox比例危险模型进行分析.
主要成果:
- 较高的夜间照明暴露 (91至100百分位数) 与黑暗夜间 (0至50百分位数) 相比,与冠状动脉疾病,心肌梗塞,心力衰竭,心房动和中风的风险显著增加有关.
- 在调整多个心血管风险因素后,关联仍然很强.
- 性别和年龄改变了这些关联,女性和年轻人显示出某些心血管疾病的风险更大.
结论:
- 夜间暴露于光线是40岁以上成年人心血管疾病的重要危险因素.
- 尽量减少夜间的光线可能是心血管健康的有价值的预防策略.
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