简化面部复苏:一种随机的分裂面部试验,预先混合皮内肉毒素A型和氨酸生物复苏
Islam Alzayadneh1, Omar Hamdan2, Lana Alzayadneh3
1Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Mutah University, Karak, Jordan.
Aesthetic surgery journal
|October 23, 2025
概括
与氨酸 (HA) 生物复苏 (NCTF 135HA) 结合甲型肉毒素 (BoNT-A) 的结合,与单独使用BoNT-A相比,显著改善了面部纹和皮肤质量. 这种组合提供了卓越的结果和患者满意度,副作用最小.
科学领域:
- 皮肤病学 皮肤病学
- 审美医学是一种美学医学.
- 化品科学 化品科学
背景情况:
- 毒素A型 (BoNT-A) 有效治疗动态纹,但对整体皮肤质量影响有限.
- 基于氨酸 (HA) 的生物复苏改善了皮肤的水分,性和发光.
- 对联合使用BoNT-A和HA生物复苏的高质量的临床证据是有限的.
研究的目的:
- 为了比较单次疗程的疗效和安全性,预先混合的皮内BoNT-A与HA生物复苏 (NCTF 135HA) 与单独使用BoNT-A进行面部复发.
- 评估对纹严重程度,皮肤质量参数和患者报告结果的影响.
主要方法:
- 这是一项前性,随机,双盲,分脸试验,涉及52名参与者.
- 面部的一侧接收了BoNT-A + NCTF 135HA,而对方单独接收了BoNT-A.
- 在第60天评估的结果包括纹严重性评级量表 (WSRS),皮肤质量的视觉模拟量表和全球美学改善量表 (GAIS).
主要成果:
- 与单独的BoNT-A相比,组合疗法显示WSRS的减少显著更大 (p < .001).
- 只有在组合方面 (p < .001) 才观察到水分,度,音色均性和辐射的显著改善.
- 综合疗法的GAIS分数和患者满意度显著更高 (p < .001),94.2%的患者愿意重复该程序.
结论:
- 与NCTF 135HA预混合的皮内BoNT-A与BoNT-A单疗法相比,提供了优越的纹减少和改善皮肤质量.
- 组合治疗提供了更高的患者满意度,具有出色的安全性和最小的停机时间.
- 这种方法代表了全面面部复发的有效策略.
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