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18F-FDG PET/CT的血管吸收预测了新发多发性肌痛性风湿症的复发

Ningqi Dai¹, Xinyi Sun², Linzi Meng¹

¹Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Rheumatology (Oxford, England)

|October 23, 2025

概括

在多发性肌痛性风湿症 (PMR) 患者中,通过18F-FDG PET/CT检测到的血管参与,预测疾病复发并识别亚临床巨细胞动脉炎 (GCA). 这种成像工具有助于预后和复发预防策略.

科学领域:

类风湿病学类风湿病学
核医学就是核医学.
血管成像血管成像

背景情况:

多发性肌痛性风湿症 (PMR) 可能与亚临床巨细胞动脉炎 (GCA) 相关.
识别患有PMR复发高风险的患者对于有效管理至关重要.
18F-氧葡萄糖正子发射断层扫描/计算机断层扫描 (18F-FDG PET/CT) 是评估血管炎症的有价值的成像方法.

研究的目的:

评估18F-FDG PET/CT在检测PMR患者血管干扰方面的实用性.
确定血管参与是否与亚临床GCA和PMR中的疾病复发有关.
为了确定PMR患者复发的预测因素.

主要方法:

对80名接受18F-FDG PET/CT的PMR患者进行了回顾性队列研究.
患者根据PET/CT检测到的血管干扰被分类为组.
临床特征,治疗和复发率的比较;复发预测因子的多变量考克斯回归分析.

主要成果:

17.5%的PMR患者表现出血管干扰,93%的患者表现出脑外血管干扰,表明亚临床GCA.
在亚临床GCA患者 (71%) 和孤立PMR (29%) 患者中,复发率显著更高.
血管干扰 (HR 3.731) 强烈预测复发,而关节痛显示出保护作用 (HR 0.325).

结论:

通过18F-FDG PET/CT检测到的血管干扰是PMR复发的关键预测因素.
18F-FDG PET/CT对于识别亚临床GCA和预测PMR患者的预后非常有用.
进一步的研究是有必要的,以开发查协议和优化复发预防策略.

关键词:

18F-FDG 关于PET/CT 的研究巨细胞动脉炎的发生多肌痛类风湿症多肌痛类风湿症这是一个复发的复发.

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