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Updated: May 5, 2026

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SHICEDO:单细胞Hi-C数据增强,减少过度平滑

Jingong Huang1, Rui Ma2, Michael Strobel1

  • 1Department of Computer Science and Engineering, University of California Riverside, CA 92521, United States.

Bioinformatics (Oxford, England)
|October 23, 2025
PubMed
概括

SHICEDO使用深度学习模型增强稀疏的单细胞Hi-C数据. 这改进了3D基因组结构分析,通过准确地赋予缺失的联系和细化功能,如隔间和循环.

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Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...
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