一种细菌外毒素触发的植物免疫反应限制了病原体的生长
David Thoms1, Melissa Y Chen2, Yang Liu2
1Department of Microbiology and Immunology, The University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
Cell reports
|October 23, 2025
概括
植物可以区分有益和致病细菌,甚至是密切相关的细菌. 这种区别主要通过识别细菌外毒素来实现,从而触发植物免疫反应以控制有害微生物.
科学领域:
- 植物与微生物的相互作用
- 植物免疫力 植物免疫力
- 微生物生态学 微生物生态学
背景情况:
- 宿主生物必须平衡有益的共生关系与病原体防御.
- 区分具有不同生活方式的密切相关的微生物是宿主免疫力的关键挑战.
研究的目的:
- 为了研究植物是否能够区分类遗传学上相似的有益细菌和致病性细菌.
- 确定植物根系球中这种歧视背后的机制.
主要方法:
- 利用了两个密切相关的Pseudomonas fluorescens菌株:一个有益的,一个致病的.
- 在试验室和植物根系中评估了细菌竞争.
- 分析了植物免疫反应,包括对外毒素的感知和下游信号通路 (例如,BAK1/BKK1/CERK1).
主要成果:
- 有益的菌株在根系球中超越了病原体,尽管与微生物相关的分子模式类似.
- 植物建立了一个由外毒素触发的防御反应,专门针对致病菌株.
- 对净化的外毒素的感知诱导了植物免疫力,并以BAK1/BKK1/CERK1依赖的方式限制了细菌生长.
结论:
- 植物免疫可以区分具有不同的生活方式的基因组学上相似的微生物.
- 外毒素感知是植物识别和限制病原体的关键机制.
- 像BAK1/BKK1/CERK1这样的免疫成分在平衡有益和致病微生物生长方面发挥作用.
相关概念视频
Defenses Against Pathogens and Herbivores
29.5K
Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
29.5K
Defense Against Bacterial Pathogens
2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K
Stringent Response in E. coli
292
Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
292
Cell Signaling in Plants
6.1K
Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
6.1K
Transgenic Plants
8.4K
Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically modified organisms are called transgenic organisms.
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...
8.4K
Plant Cell Wall
60.0K
The plant cell wall gives plant cells shape, support, and protection. As a cell matures, its cell wall specializes according to the cell type. For example, the parenchyma cells of leaves possess only a thin, primary cell wall.
60.0K


