轴长作为年龄,性别和种族的函数:来自CLEERE研究的结果
Donald O Mutti1, Loraine T Sinnott1, Susan A Cotter2
1College of Optometry, The Ohio State University, Columbus, Ohio.
概括
儿童的轴长是由年龄,性别和种族所塑造的,在年幼的儿童和特定的种族模式中显示出更快的延长. 这些数据有助于近视控制研究和临床评估.
科学领域:
- 眼科医生 眼科 眼科
- 儿科眼科医生 儿科眼科医生
- 近视研究 近视研究
背景情况:
- 轴长是近视控制有效性的关键指标.
- 对轴长度的准确建模对于临床试验和个体患者评估至关重要.
研究的目的:
- 开发儿童近视和一般儿科患者的轴长度模型.
- 分析年龄,性别,种族/民族,父母近视,近工作和户外活动对轴长度的影响.
主要方法:
- 采用正方形匹配来基于年龄,性别,种族/种族和其他共同变量的轴长度建模.
- 分析了CLEERE研究中的590名近视儿童的数据,每年进行多次访问.
- 轴长百分位是通过使用来自近5000名儿童的23,000多个观察结果来确定的.
主要成果:
- 轴延长在较年轻的儿童 (6-14岁) 中最大,并遵循二次轨迹.
- 与黑人和白人相比,亚裔美国人,美洲原住民和西班牙裔儿童的轴长度增加更为急剧.
- 女性的轴长较短,但近视的概率较高,相对于他们的年龄和百分位数;父母的病史和生活方式因素在多变量模型中并不是显著的预测因素.
结论:
- 根据年龄,性别和种族/种族的轴长度模型,以及百分位数,是有价值的工具.
- 这些模型可以帮助规划近视控制临床试验的样本大小.
- 这些发现支持使用轴长模型来判断近视控制的有效性,并将当前数据与历史数据集进行比较.
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