母亲维生素D补充剂对儿童健康的影响
Nanna S Svensson1,2, Tabia Volqvartz2, Anna Louise Vestergaard1,2
1Department of Obstetrics and Gynaecology, Regional Hospital Randers, 8930 Randers, Denmark.
Endocrine reviews
|October 23, 2025
概括
怀孕期间补充维生素D可能会减少婴儿感染并改善发育,但当前剂量可能无法预防缺乏. 需要更多的研究来优化母亲的维生素D水平,以改善儿童的健康.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
背景情况:
- 怀孕期间的维生素D缺乏对后代健康构成风险.
- 目前的指导方针建议补充,但缺乏对最佳母体水平的共识.
- 了解维生素D对特定器官的影响对于优化产前补充剂至关重要.
研究的目的:
- 审查怀孕期间维生素D补充剂 (≥400 IU/d) 的下一代影响.
- 探索特定的母体维生素D水平是否与观察到的益处相关.
- 评估目前的建议是否足以确保婴儿维生素D的充足.
主要方法:
- 在PubMed和Embase的系统文献搜索中,遵循PRISMA指南.
- 包括的研究重点关注从分娩后10天起的健康结果.
- 在2383篇选文章中分析了38项研究.
主要成果:
- 在11/16项研究中,维生素D补充剂减少了儿童早期的呼吸道感染.
- 在6/12项研究中,发现了对生长和骨发育的好处.
- 对神经发育和降低自身免疫风险的潜在积极影响需要进一步研究.
- 即使在每天补充1600 IU时,也观察到婴儿维生素D缺乏率很高,这表明目前的建议可能不足.
结论:
- 产前维生素D补充剂有望减少婴儿感染并支持发育.
- 目前的补充指南可能无法保证出生时足够的维生素D水平,增加感染风险.
- 进一步研究将母亲/婴儿维生素D水平与特定结果联系起来,对于个性化的产前营养和改善下一代健康至关重要.
相关概念视频
Role of Skin in Vitamin D Synthesis
7.5K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.5K
Vitamins
2.3K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.3K
Role of Vitamins in Maintaining Bone Health
5.0K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.0K
Environmental Influences on Intelligence
881
Despite the strong genetic influence on traits like intelligence, environmental factors significantly shape outcomes. For example, while over 90% of height variation is due to genetic differences, environmental factors such as nutrition also have a notable impact. Similarly, for intelligence, changes in a child's surroundings can significantly alter their IQ. Research shows that enriched environments boost children's academic success and help them develop key cognitive skills. Children...
881
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
241
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
241
Nature and Nurture
22.2K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
22.2K


