在怀孕前,怀孕期间和怀孕后测量抗抑郁药的持续暴露:一个范围审查协议
Lauren S Tailor1,2, Hilary K Brown2,3, Jessie Cunningham1,4
1Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada.
PloS one
|October 23, 2025
概括
本综述探讨了研究如何衡量孕妇使用抗抑郁药的情况. 它旨在标准化测量以更好地了解围产期抗抑郁药物暴露.
科学领域:
- 围产期心理健康研究
- 怀孕期间的药监督
- 生殖精神病学是一种精神病学.
背景情况:
- 由于证据有限,医疗保健提供者在怀孕期间管理抗抑郁药的使用面临挑战.
- 关于围产期抗抑郁药物暴露的先前研究产生了不一致的结果,通常使用简化暴露分类.
- 准确测量抗抑郁药的使用对于了解围产期结局至关重要.
研究的目的:
- 进行对测量抗抑郁药继续/停止的研究进行范围审查.
- 总结抗抑郁药在怀孕前,怀孕期间和怀孕后使用的测量方法.
- 在围产期研究中提供持续抗抑郁药物暴露的标准化定义.
主要方法:
- 根据JBI手册和PRISMA-ScR指南进行范围审查.
- 在多个数据库 (MEDLINE,EMBASE,PsycINFO等) 中进行全面的文献搜索. 和灰色文学.
- 由两位独立审查员提取数据,重点关注抗抑郁药物暴露的时间,持续时间,坚持和确定.
主要成果:
- 该审查将综合有关先前研究中抗抑郁药的持续/停止如何被测量的发现.
- 基于用于评估围产期抗抑郁药物暴露的方法来对研究进行分类.
- 识别测量方法中的差距和一致性.
结论:
- 这次审查将澄清之前的研究在多大程度上测量了持续使用抗抑郁药物的程度.
- 这些发现将指导未来围产期研究中对抗抑郁药物暴露的准确定义的开发.
- 改进的测量将提高对母亲和婴儿结果的研究可靠性.
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