布雷克西普拉用于治疗同时发生的精神分裂症和物质使用障碍:一个多站点,随机,受控试验
Xiaoduo Fan1,2, Oliver Freudenreich3, L Fredrik Jarskog4
1UMass Mind Clinical and Research Program, UMass Memorial Health/University of Massachusetts Chan Medical School, Worcester, Massachusetts.
The Journal of clinical psychiatry
|October 23, 2025
概括
布雷克西普拉治疗显示,在精神分裂症和物质使用障碍患者中减少物质使用和渴望的潜力,从而改善生活质量. 需要进一步的研究来证实这些发现,在这个难以治疗的人群.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 成 药物 药物 药物 药物
背景情况:
- 精神分裂症和物质使用障碍经常同时发生,带来复杂的治疗挑战.
- 对于这种双重诊断群体的现有治疗方法的疗效有限.
- 确定有效的药理干预措施对于改善患者的治疗结果至关重要.
研究的目的:
- 调查布雷克斯皮普拉在治疗精神药物使用,精神病症状和精神分裂症和物质使用障碍同时发生的患者的生活质量方面的疗效.
- 为了在12周的时间内比较布雷克斯皮普拉治疗与通常治疗 (TAU).
主要方法:
- 一个为期12周的随机对照试验,涉及被诊断患有精神分裂症和物质使用障碍的患者.
- 参与者被分配给brexpiprazole (高达4毫克/天) 或TAU.
- 评估包括物质使用频率和成本,渴望 (视觉模拟量表),生活质量 (亨利希斯-卡宾特QOL量表) 和精神症状 (PANSS,CGI-S).
主要成果:
- 虽然不具有统计学意义,但布雷克斯皮普拉组显示出与TAU相比,减少物质使用日和消费的趋势,以及减少渴望.
- 布雷克斯皮普拉群体在生活质量上显示出统计学上显著的改善 (8.9个点的增长,P=.020).
- 在brexpiprazole组中,在一般精神病理和PANSS上的负面症状方面观察到改善的趋势.
结论:
- 布雷克西普拉在降低伴随性精神分裂症和物质使用障碍患者的物质渴望和使用方面可能有好处.
- 布雷克斯皮普拉改善生活质量和精神症状的潜力需要在这个人群中进一步调查.
- 布雷克西普拉对这一具有挑战性的患者群体来说是一个潜在的治疗选择.
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