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相关概念视频

Thermosensation01:43

Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Decreased Body Temperature01:29

Decreased Body Temperature

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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Nociception01:44

Nociception

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Factors Affecting Body Temperature01:28

Factors Affecting Body Temperature

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As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may  include:
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相关实验视频

Updated: Jan 14, 2026

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
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Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

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与年龄相关的热痛耐受性下降与C纤维功能和局部皮肤血管扩张的同时下降有关.

Bruno Rojas-Roel1, Julia Devanne1, Olivier Després1

  • 1Université de Strasbourg, CNRS, LNCA UMR 7364, 12 rue Goethe, F-67000, Strasbourg, France.

Autonomic neuroscience : basic & clinical
|October 23, 2025
PubMed
概括
此摘要是机器生成的。

由于皮肤血管扩张减少,衰老会降低耐热疼痛的耐受性,阻碍散热. 降低C纤维功能可能会导致老年人的这种衰退.

关键词:
衰老的衰老 衰老的衰老这是C纤维.皮肤血管扩张 皮肤血管扩张局部热性高血压 (LTHH).疼痛耐受性 疼痛耐受性

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Determining heat and mechanical pain threshold in inflamed skin of human subjects
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Determining heat and mechanical pain threshold in inflamed skin of human subjects

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Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
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Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

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Determining heat and mechanical pain threshold in inflamed skin of human subjects
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Determining heat and mechanical pain threshold in inflamed skin of human subjects

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科学领域:

  • 生理学 生理学 生理学
  • 老年学是一门学科.
  • 疼痛研究 疼痛研究

背景情况:

  • 衰老与改变的温度调节和疼痛感知有关.
  • 皮肤血管扩张对于散热和维持热平衡至关重要.
  • 在热痛耐受性与年龄相关的变化中,C纤维功能的作用需要进一步研究.

研究的目的:

  • 为了研究皮肤血管扩张和热痛耐受性在衰老中的关系.
  • 检查C纤维功能与皮肤血管扩张功效之间的关联.
  • 确定导致老年人耐热疼痛减弱的因素.

主要方法:

  • 耐热性疼痛耐受性测试,持续监测疼痛和皮肤温度.
  • 使用激光多普勒流量计评估皮肤血管扩张的局部热性高血压协议.
  • 热检测和热疼痛值测量,以评估小纤维 (C-纤维) 的功能.

主要成果:

  • 与耐热性较低的老年人 (老年人LOW) 相比,与耐热性较高的年轻人和老年人 (老年人MAX) 相比,耐热性较低的老年人表现出减少的热引起的血管扩张.
  • 较老的LOW受试者在耐受性测试期间经历了较高的皮肤温度和疼痛评级.
  • 在较老的LOW受试者中观察到C纤维功能下降,由更高的热检测值表明.

结论:

  • 减少皮肤血管扩张,可能与C纤维功能受损有关,对衰老中的热痛耐受性产生负面影响.
  • 由于血管扩张受损,散热效率低下会导致一些老年人的热痛耐受性降低.
  • 准C纤维功能和改善皮肤血管扩张可能是提高老年人耐热疼痛的潜在策略.