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Hongyu Liu¹, Buling Wu²

¹Shenzhen Clinical College of Stomatology, School of Stomatology, Southern Medical University, Shenzhen, Guangdong, China; Shenzhen Stomatology Hospital (Pingshan) of Southern Medical University, Shenzhen, Guangdong, China; Stomatology Hospital of Southern Medical University, Guangzhou, Guangdong, China.

Archives of oral biology

|October 23, 2025

概括

杜利霍尔酸盐曼诺合成酶 (DPMS) 子单元DPM1和DPM2在口腔状细胞癌 (OSCC) 中被上调. 高DPM1表达表明OSCC患者的预后较差,这表明它是潜在的治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

口腔状细胞癌 (OSCC) 是一种常见的恶性瘤,具有复杂的分子基础.
多利胆酸盐曼诺合成酶 (DPMS) 对于N-甘化至关重要,这是一个涉及癌症进展的过程.

研究的目的:

在OSCC中调查DPMS子单位 (DPM1,DPM2,DPM3) 的预后意义.
探索DPMS亚单元表达与OSCC患者结果和瘤免疫微环境之间的关联.

主要方法:

使用了癌症基因组图谱 (TCGA),Metascape和MethSurv进行全面分析.
在OSCC细胞系和组织上进行实时定量聚合酶链反应 (RT-qPCR) 进行验证.
进行了单变体和多变体的COX分析,基因本体学 (GO) 分析和基因组丰富分析 (GSEA).

主要成果:

与正常组织相比,OSCC组织中的DPM1和DPM2表达水平显著升高.
高DPM1表达是OSCC患者整体存活率较低的独立预测因子.
在OSCC中,DPMS亚单元表达与细胞周期,核酸代谢,翻译途径和免疫细胞透相关.

结论:

作为DPMS子单位的DPM1显示出作为OSCC中不良结果的预后生物标志物的潜力.
DPMS子单位可能代表OSCC治疗策略的新疗法目标.

关键词:

生物信息学分析生物标志物生物标志物这是一个DPMS,DPMS是DPMS.口腔状细胞癌的癌症.预测值的预测值是指预测值的预测值.

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