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Updated: Jan 14, 2026

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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选和鉴定具有α,β不和胺基结构的共价Nrf2激活剂

Yasuhiko Izumi1, Norihiko Takeda2, Shuzo Nishimoto1

  • 1Laboratory of Pharmacology, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.

Bioorganic & medicinal chemistry
|October 23, 2025
PubMed
概括

研究人员确定了KU-0479,一种新型化合物激活Nrf2通路,增强细胞防御氧化应激. 这种强大的激活剂对与氧化损伤相关的疾病具有治疗潜力.

关键词:
在Keap1Nrf2路径中.它具有抗氧化作用的抗氧化作用.化学图书馆 化学图书馆结构活动关系结构活动关系

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