评估阻塞性睡眠呼吸暂停-呼吸暂停综合征对刺激性肠综合征的影响
Guangqin Wu1, Yanfei Fang1, Yu Hong2
1Department of Gastroenterology, Taicang Affiliated Hospital of Soochow University, Suzhou, 215400, China.
阻塞性睡眠呼吸暂停-呼吸暂停综合征 (OSA) 显著增加了刺激性肠综合征 (IBS) 的风险和症状严重程度. 持续的正气道压力 (CPAP) 治疗有效地改善了伴随性OSS患者的IBS症状.
科学领域:
- 胃肠病学 胃肠病学
- 睡眠医学 睡眠医学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 刺激性肠综合征 (IBS) 是一种慢性功能性胃肠疾病.
- 缺氧,特别是阻塞性睡眠呼吸暂停-缺氧综合征 (OSA) 的缺氧,越来越被认为是IBS的潜在促成因素.
- 这项研究调查了OSA和IBS之间的关系,以及OSA相关的缺氧对IBS症状的影响.
研究的目的:
- 为了检查阻塞性睡眠呼吸暂停-呼吸暂停综合征 (OSA) 对刺激性肠综合征 (IBS) 的风险和严重性的影响.
- 评估持续正气道压力 (CPAP) 疗法在同时患有OSA的患者改善IBS症状的疗效.
主要方法:
- 582名患者被分为IBS和非IBS组.
- 使用逻辑回归分析了OSA严重程度 (呼吸暂停-呼吸暂停指数 - AHI) 与缺氧和IBS之间的关联.
- 在患有OSA和IBS的患者中,在CPAP治疗前后比较IBS严重性评分系统 (IBS-SSS) 评分.
主要成果:
- 患有IBS的患者的AHI明显高于非IBS患者 (P=0.002).
- 增加的OSA和缺氧严重程度与增加的IBS风险和症状得分相关 (P趋势<0.001).
- CPAP治疗导致IBS-SSS得分在3个月和6个月显著降低 (P < 0.001).
结论:
- OSA与发展IBS的风险增加有关.
- 合并性OSA和缺氧会加剧IBS症状.
- CPAP疗法是改善OSA患者IBS症状的有效治疗方法.
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