来自利比里亚的患有慢性乙型肝炎病毒感染的患者中肝炎D病毒阳性
Joseph A Akambase1, Spencer R Goble2, Yasmin O Ali1
1Department of Medicine, Hennepin Healthcare, Minneapolis, Minnesota.
The American journal of tropical medicine and hygiene
|October 23, 2025
概括
肝炎D病毒 (HDV) 感染显著恶化慢性肝炎B病毒 (HBV) 肝病和癌症风险. 建议在HBV患者中进行HDV的普遍查,因为错过了检测机会,特别是在高危人群中.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 病毒性肝炎病毒性肝炎
背景情况:
- 肝炎D病毒 (HDV) 感染加剧慢性肝炎B病毒 (HBV) 相关的肝病,增加肝细胞癌 (HCC) 风险.
- 大型肝炎病毒的同时感染是一个重大的全球健康问题,特别是在HBV阳性个体中.
研究的目的:
- 评估在城市安全网医院的HBsAg阳性患者中HDV感染的流行率.
- 为了确定HDV共感染的风险因素,并评估查实践.
主要方法:
- 对1337名HBsAg阳性患者进行了回顾性队列研究.
- 分析抗HDV抗体测试,PCR确认和临床数据,包括肝硬化,HCC,HIV,HCV和酒精使用.
- 后勤回归分析以确定HDV阳性的独立预测因素.
主要成果:
- 41.6%的患者进行了高强度病毒检测;8.8%的患者呈抗高强度病毒阳性,28%的患者通过PCR得到证实.
- 高密度病毒阳性患者的肝硬化率 (34.7%对12.2%) 和高密度肝硬化率 (6.1%对2.8%) 较高.
- 高血压病毒阳性的独立预测因素包括黑人种族,肝硬化,升高的AST和低的HBVDNA水平.
结论:
- 观察到大量的HDV查不足,特别是在像利比里亚患者这样的高患病率群体中.
- 基于风险的查错过了HVD检测的机会.
- 建议在HBsAg阳性个体中进行全方位HDV查,以改善患者的治疗结果.
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