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通过4D蒙特卡洛模拟来量化HDR骨干疗法中后载器特定源动态的剂量学影响

F Moradi^1,2, D A Bradley^3,4, A Taheri³

¹Department of Biomedical Imaging, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.

Physics in medicine and biology

|October 23, 2025

概括

这项研究量化了源运动在高剂量率 (HDR) 前列腺支臂治疗中的剂量学影响. 在治疗规划期间忽视源传输剂量可能会导致严重低估前列腺和周围危险器官 (OAR) 的剂量.

科学领域:

医学物理医学物理
辐射瘤学辐射瘤学
计算生物学计算生物学

背景情况:

高剂量率 (HDR) 支臂疗法是前列腺癌的合规辐射疗法技术.
当前的治疗计划系统往往忽略了放射性源移动 (过境剂量) 期间提供的剂量.
在商业系统之间,后载源动态在商业系统之间有很大差异.

研究的目的:

量化后装载器特定源动态在HDR前列腺支架治疗中的剂量学影响.
评估源传输剂量对目标器官和有风险的器官 (OAR) 的贡献.
为了比较不同HDR后装模型的过境剂量效应.

主要方法:

使用TOPAS平台进行时间解析 (4D) 蒙特卡洛 (MC) 模拟.
三个商用HDR后载器 (Varian GammaMedPlus,BEBIG MultiSource,Elekta microSelectron) 的建模,它们具有不同的源加速配置.
模拟各种针和停留点配置,以评估传递剂量到瘤,前列腺体,膀和直肠.

主要成果:

增加的针头和停留数量将过境剂量提高到目标和OAR.
在后载机中,低源加速会产生显著更高的中转剂量.
前列腺体获得了约14.2%的处方瘤剂量,其中~10.2%来自过渡效应.
过渡剂量贡献被发现具有临床意义,特别是在目标-OAR分离有限的情况下.

结论:

在HDR支臂疗法期间的源运动显著影响剂量分配.
当前的治疗计划系统可能会低估OAR剂量,忽视源传输效应.
纳入源传输剂量计算对于准确的剂量估计和改善前列腺支架治疗患者的结果至关重要.

关键词:

4D蒙特卡洛模拟的模拟在HDR手臂疗法中,使用HDR手臂疗法.在后装载机后装载机.时间特征时间特征.过境剂量的过境剂量

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