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探索imidazothiazole和imidazopyrimidine碳酸胺对增强抗结核活性的研究

Oluseye K Onajole1, Shichun Lun2, Dakoju Ravi Kishore3

  • 1Department of Biological, Physical and Health Sciences, College of Health, Science and Pharmacy, Roosevelt University, 425 S. Wabash Avenue, Chicago, IL 60605, USA; Department of Pharmaceutical Sciences, University of Illinois Chicago College of Pharmacy, Chicago, IL 60612, USA.

Bioorganic & medicinal chemistry letters
|October 23, 2025
PubMed
概括

研究人员开发了一种新型的异体双环碳胺,用于对抗耐药结核病 (TB). 化合物21和37对易感,多药耐药 (MDR) 和广泛耐药 (XDR) 结核病菌株表现出强烈的活性,具有良好的类似药物的特性和选择性.

关键词:
药物耐药的Mtbb是一种抗药性药物.伊米达佐[2,1-b]胺-5-碳胺化物伊米达佐 (Imidazo) [2,1-b]亚-5-碳胺化物伊米达索皮里米丁是一种伊米多西雅 (Imidothiazole) 是一种结核病菌菌菌的结核病菌的结核病菌.结构活动关系 结构活动关系

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