周围分娩的氧化和炎症状况及其与能量代谢和过渡期奶牛的表现的关系
M Q Zhang1, S Heirbaut2, K Hertogs3
1Institute of Animal Husbandry and Veterinary Science, Jiangxi Academy of Agricultural Sciences, Nanchang, Jiangxi 330200, China; Laboratory for Animal Nutrition and Animal Product Quality, Department of Animal Sciences and Aquatic Ecology, Faculty of Bioscience Engineering, Ghent University, B-9000 Ghent, Belgium.
Journal of dairy science
|October 23, 2025
概括
乳牛抗氧化能力较低的乳牛在早期哺乳期经历更多的代谢压力和减少的牛奶产量. 较高的抗氧化能力和缺乏临床症状有助于奶牛控制炎症,表明不同的健康状况.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 动物生理学 动物生理学
- 乳制品科学 乳制品科学
背景情况:
- 代谢,氧化和炎症状态之间的相互作用对于过渡期的奶牛健康至关重要.
- 这些状态的精确相互关系及其对奶牛生理学的影响需要进一步阐明.
研究的目的:
- 在过渡期内调查乳牛的代谢,氧化和炎症状态之间的相互作用.
- 根据抗氧化剂和炎症概况识别不同的奶牛群体,并评估它们的生理后果.
主要方法:
- 集群分析 (模糊的c-means和k-medoids) 用于根据氧化变量和急性阶段蛋白 (APPs) 在相对于分娩的-7和21天对66只Holstein Friesian奶牛的哺乳期进行分类.
- 分析了代谢标记物 (BHBA,非化脂肪酸,胰岛素),氧化变量 (GSSG,GPx,SOD,MDA,ORAC) 和APP (Hp,SAA,A:G) 等.
主要成果:
- 确定了两个抗氧化能力组:较低的抗氧化能力 (LAA80%) 和较高的抗氧化能力 (HAA80%).
- 临床上健康的奶牛被分为急性反应阶段 (APR) 和非APR组.
- LAA80%的奶牛显示代谢压力增加 (BHBA升高),牛奶产量减少,牛奶脂肪百分比增加,特别是在产后5-21天之间.
- 患病的奶牛表现出更高的GPx活性和BHBA度.
- 在抗氧化能力受损和炎症增强之间发现了温和的关联;与APR和患病群体相比,非APR奶牛在分娩前的SAA水平较低.
结论:
- 乳牛在早期哺乳期表现出异质的氧化和炎症特征.
- 牛奶牛的氧化状况下降需要密切监测.
- 具有较高抗氧化能力且没有临床症状的奶牛可以在过渡期有效地管理炎症反应.
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