简要报告:肺作为晚期非小细胞癌患者和接受免疫检查点抑制剂的COPD患者的预后因素
Madeleine Di Frisco1, Miguel F Sanmamed2, José María Ferrández3
1Pulmonary Department, Clinica Universidad de Navarra, Pamplona, Spain; Department of Oncology, Clinica Universidad de Navarra, Pamplona, Spain.
概括
在接受免疫治疗的慢性阻塞性肺病 (COPD) 和晚期非小细胞肺癌 (aNSCLC) 患者中,肺气的存在与显著更长的整体存活率有关. 这一发现表明肺气可能在这个患者群体中作为预后标志物.
科学领域:
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 慢性阻塞性肺病 (COPD) 和肺气是众所周知的肺癌风险因素.
- 这两种情况都独立地与接受免疫检查点抑制剂 (ICI) 治疗的高级非小细胞肺癌 (aNSCLC) 患者的生存率提高有关.
- 在接受免疫治疗的aNSCLC患者中,COPD和肺气的综合预后影响尚不清楚.
研究的目的:
- 评估COPD和接受免疫治疗的高级非小细胞肺癌 (aNSCLC) 患者肺气的预后作用.
- 为了确定肺气的存在是否会影响这一特定患者队列的整体存活率 (OS) 和无进展存活率 (PFS).
主要方法:
- 对111名患有aNSCLC和COPD (通过螺旋测量定义) 的患者进行了回顾性分析,这些患者接受了单剂ICI治疗.
- 患者根据在胸部计算机断层扫描 (CT) 上视觉检测到的肺气的存在或不存在来分类.
- 总生存率 (OS) 和无进展生存率 (PFS) 在各组之间进行了比较,使用多变量分析来确定独立的预后因素.
主要成果:
- 在111名COPD患者中,有77名患者同时患有肺气.
- 与没有肺气 (8.5个月;p = 0.008) 相比,COPD和肺气患者的寿命显著更长 (17.3个月).
- 肺被确定为更好的OS的独立因素 (危险比:0.49;95%CI:0.30-0.81),在各组中具有相似的不良事件率.
结论:
- 胸部CT上可视检测到的肺气可以作为接受ICI的aNSCLC和COPD患者的有价值的预后标记.
- 需要进一步的研究来验证这些发现,并探索潜在的机制.
- 这项研究强调了在对接受免疫治疗的COPD肺癌患者的预后评估中考虑肺气的重要性.
相关概念视频
Chronic Obstructive Pulmonary Disease
2.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.2K
Chronic Obstructive Pulmonary Disease-I: Introduction
3.6K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.6K
COPD: Pathogenesis and Clinical Features
1.8K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.8K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.2K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
3.5K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.5K
COPD: Management Using Bronchodilators and Corticosteroids
722
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
722

