糖尿病病中的NETosis:分子机制和治疗机会
Akash Kumar Mourya1, Juhi Pradeep Churi1, Nangshanbok Wahlang1
1Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) SAS Nagar, Sec 67, Mohali, Punjab, 160062, India.
中性粒细胞外细胞陷 (NETs) 有助于糖尿病病 (DKD) 的进展. 向NETosis显示出治疗前景,但需要平衡疗效与免疫功能保护,以获得更好的DKD患者结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 糖尿病病 (DKD) 是导致衰竭的主要原因,治疗方法有限.
- 中性粒细胞死亡的一种形式NETosis,释放中性粒细胞外细胞陷 (NETs),与DKD有关.
- 高血糖症通过活性氧物种 (ROS),流入,PAD4和NADPH氧化酶驱动NETosis.
研究的目的:
- 审查将NETosis与DKD病原体联系起来的分子机制.
- 为突出糖尿病患者中新兴的NETosis生物标志物.
- 批判性地评估针对DKD中NETosis的当前和新兴疗法.
主要方法:
- 关于分子机制和临床研究的文献综述.
- 在DKD患者中分析与NETosis相关的生物标志物.
- 评估治疗策略,包括PAD4抑制剂,DNase,甲胺和维生素D.
主要成果:
- 网症通过内皮功能障碍,细胞损伤和纤维化加剧损伤.
- 生物标志物,如MPO-DNA复合物,素基因素 (CitH3) 和NE在DKD患者中升高.
- 目前的疗法在平衡治疗效果与保护免疫防御方面面临挑战.
结论:
- 向NETosis为DKD治疗提供了潜力,但翻译是复杂的.
- 需要进一步的研究来解决患者异质性和优化治疗策略.
- 针对性NETosis调节的精细方法对于改善DKD结果至关重要.
更多相关视频
07:15Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
Published on: August 23, 2024
08:15Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
Published on: May 10, 2024
相关概念视频
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Nephrotic Syndrome I : Introduction
Acute Kidney Injury II: Pathophysiology
Chronic Kidney Disease III: Interprofessional Care
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
