在第三级护理癌症中心的活跃Candida auris分子监测计划的产量
Krupa Jani1, Tracy McMillen1, Cindy Lee1
1Clinical Microbiology Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
The Journal of molecular diagnostics : JMD
|October 23, 2025
概括
在重症监护室对Candida auris (C. auris) 的积极监测发现了五年来16起病例. 尽管阳性率低,但病例的增加凸显了持续查的必要性,以防止这种多药耐药酵母菌的传播.
科学领域:
- 传染性疾病 传染性疾病
- 医学微生物学 医学微生物学
- 公共卫生监督 公共卫生监督
背景情况:
- 黄是一种严重的全球健康威胁,因为它具有多种药物耐药性和潜在的疫情爆发.
- 建议在纽约等可报告C. auris的地区对高风险患者进行积极监测.
研究的目的:
- 评估通过积极监测测试发现的Candida auris病例的产量和特征.
- 分析实时PCR查在三级癌症护理环境中的有效性.
主要方法:
- 在第三级癌症护理中心对2019-2023年监测数据的回顾性审查.
- 实时PCR测试来自ICU患者的下,鼻子和沟抽样.
- 对阳性PCR样本进行培养,全基因组测序和抗真菌敏感性测试.
主要成果:
- 在27,299个测试样本中检测到来自16名独特患者的139个阳性样本 (0.5%).
- 部 (39.5%) 和鼻子 (31.7%) 是最常见的阳性抽样部位.
- 80%的分离物体对可纳产生了耐药性;除了一个 (III类) 之外,所有分离物体都属于I类.
结论:
- 积极监测检测到Candida auris病例数量较少但越来越多,强调其在高风险人群中的重要性.
- 这些发现强调需要持续保持警和查,以制这种耐药性病原体的传播.
- 基因组数据证实了类分布,并突出显著的抗真菌耐药性.
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