被遗弃的青少年:在喘随机对照试验中代表人数不足
Amy G Nuttall1, Catherine McNamara2, William Bedson3
1Institute in the Park, University of Liverpool Department of Women's and Children's Health, Liverpool, Merseyside, UK amynuttall@doctors.org.uk.
BMJ paediatrics open
|October 23, 2025
概括
青少年喘研究是有限的,因为大多数临床试验没有报告青少年的参与. 在报告时,用于喘治疗的随机对照试验 (RCT) 中青少年的比例通常很低.
科学领域:
- 临床药理学 临床药理学
- 儿科肺病学 儿科肺病学
- 基于证据的医学基于证据的医学.
背景情况:
- 在青少年中有效的喘管理需要对治疗有效性和安全性的强有力的证据.
- 青少年代表着一个独特的生理群体,需要特定的数据来提供最佳的护理.
- 目前的研究环境可能没有充分反映喘药物治疗中的青少年特异性结果.
研究的目的:
- 评估青少年在喘治疗的随机对照试验 (RCT) 的招募和报告情况.
- 确定2015年至2023年期间发表的制药性喘RCT中包括的青少年的比例.
- 评估已发表的喘RCT中青少年子组数据的可用性.
主要方法:
- 在多个数据库中系统搜索涉及药物喘治疗的RCT.
- 纳入标准:2015年至2023年期间招募青少年和成年人的试验.
- 数据提取的重点是招募的青少年数量/比例,并报告了子组数据.
主要成果:
- 确定了81个RCT;49个 (60.5%) 没有报告青少年招募人数或比例.
- 在报告青少年纳入试验的试验中,这一比例在1%至49%之间,中位数为6.1%.
- 只有7个 (8.6%) 的试验提供了针对青少年子组的具体数据进行分析.
结论:
- 发表的喘RCT经常缺乏关于青少年招募的明确性.
- 在报告时,喘RCT中纳入的青少年比例通常很低.
- 建议在推断成年人对于青少年喘管理的数据时谨慎使用,这是由于潜在的代表性不足和缺乏子组分析.
相关概念视频
01:30Asthma-IV: Diagnostic and Management
3.1K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.1K
01:26Asthma-II: Pathophysiology and Classification
4.1K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.1K
01:29Asthma-I: Introduction
3.4K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.4K
01:20Asthma: Pathogenesis and Management
1.2K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.2K
01:24Asthma-III: Symptoms and Complications
3.3K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
3.3K
01:25Antiasthma Drugs: β2-Adrenoceptor Agonists
1.6K
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
1.6K