与免疫检查点抑制剂相关的低体质炎
Andrea Corsello1, Rosa Maria Paragliola2, Francesco Torino3
1Centro di Eccellenza Malattie Gastrointestinali e Endocrino-Metaboliche, Unità di Chirurgia Endocrina, Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
Endocrinology and metabolism clinics of North America
|October 23, 2025
概括
免疫检查点抑制剂 (ICI) 可以导致低血清炎,这是内分泌的副作用. 诊断是临床的,治疗涉及激素替代,而不是停止免疫治疗.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 在癌症治疗中至关重要.
- ICI可以触发与免疫相关的不良事件 (irAEs).
- 与ICI相关的低血清炎 (IRH) 是一种显著的内分泌IRAE,通常与抗CTLA-4疗法有关.
研究的目的:
- 描述ICI相关的低体质炎的临床表现和管理.
- 突出IRH的诊断挑战和治疗策略.
主要方法:
- 基于患者表现的临床诊断.
- 评估垂体激素功能的评估.
- 激素替代疗法. 激素替代疗法.
主要成果:
- IRH通常表现为中央上腺功能不充分.
- 其他垂体激素缺陷可能并存.
- 由于缺乏特定标志物,诊断依赖于临床评估.
结论:
- 与ICI相关的低性炎需要临床诊断.
- 管理包括激素替代疗法.
- 停止免疫疗法和高剂量的葡萄皮质激素通常是不必要的.
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