[血清非HDL-C与心血管疾病死亡风险之间的关联]
1School of Public Health, Zhejiang University, Hangzhou 310058, China Chronic Disease Prevention and Control Division, Yuecheng District Center for Disease Control and Prevention (CDC), Shaoxing 312000, China.
概括
高血清非高密度脂蛋白胆固醇 (非HDL-C) 水平显著增加心血管疾病 (CVD) 死亡的风险,包括中风和冠心病 (CHD). 这种高风险在男性,吸烟者,饮酒者和糖尿病患者中更为明显.
科学领域:
- 心血管流行病学心血管流行病学
- 公共卫生 公共卫生
- 脂质代谢 脂质的代谢
背景情况:
- 非高密度脂蛋白胆固醇 (非HDL-C) 是心血管疾病 (CVD) 的新兴风险因素.
- 对于公共卫生战略来说,了解社区人口中非HDL-C和心血管疾病死亡率之间的关联至关重要.
研究的目的:
- 研究血清非HDL-C水平与心血管疾病 (CVD),包括冠心病 (CHD) 和中风等心血管疾病的死亡率之间的关系.
- 确定潜在较高风险的子组,与高的非HDL-C相关.
主要方法:
- 一个回顾性队列研究,涉及39 038名40岁以上的参与者,没有先前的心血管疾病史.
- 利用了来自城区卫生信息平台的数据,平均随访时间为52.3个月.
- 采用Cox的比例危险模型来评估非HDL-C水平与心血管疾病死亡率之间的关联,并对子组进行分析.
主要成果:
- 在较高的非HDL-C水平和心血管疾病死亡风险增加之间发现了显著的积极关联 (HRs从1.24到2.31不等).
- 升高的非HDL-C也与较高的心血管疾病死亡风险有关 (HRs从1.39到2.53).
- 在非HDL-C和性别,吸烟,饮酒和糖尿病之间观察到显著的相互作用,这表明这些子组的风险增加.
结论:
- 血清非HDL-C水平的增加独立地与心血管疾病,包括中风和心血管疾病的死亡风险增加有关.
- 与高非HDL-C相关的心血管疾病死亡风险在男性,糖尿病患者,吸烟者和饮酒者中被放大.
- 社区卫生管理应优先考虑非HDL-C监测,并为高风险人群实施个性化脂质管理.
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