大脑细胞tDCS以区域特定的方式调节皮质皮质功能网络
Joseph Dust1,2, Laura C Rice1,3, Marissa M Lee1,4
1Department of Neuroscience, American University, Washington, DC 20016.
概括
大脑小脑刺激会以不同的方式影响大脑网络:后部中线刺激会影响默认模式网络,而后侧刺激会影响前端对象网络,从而影响认知状态.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 神经成像是一种神经成像.
背景情况:
- 小脑与大脑皮层广泛连接,被假定是协调皮层通信.
- 预计区域小脑活动对皮质功能连接 (FC) 有网络特异性影响.
- 小脑调制影响皮质FC的精确机制在很大程度上仍未被探索.
研究的目的:
- 为了调查大脑小脑跨直流刺激 (tDCS) 是否以及如何影响不同大脑皮层网络内的静止状态功能连接 (FC).
- 确定调节特定的小脑子子区域是否会导致皮质FC的网络特异性变化.
主要方法:
- 成年参与者 (n=33) 接受了20分钟,1.5mA的tDCS,准后中线或右后侧小脑.
- 参与者在单独的MRI会议中接受了阳极,阴极或假的tDCS.
- 分析了tDCS后静止状态fMRI数据,使用多变量模式分析和基于种子的连接来评估皮质FC的变化.
主要成果:
- 后中间线tDCS调制FC主要在默认模式网络 (DMN) 中.
- 在前侧小麦细胞网络 (FPN) 中,前侧小麦细胞tDCS改变了FC.
- 后部中线刺激增加了DMN内部的FC,减少了网络间的FC (DMN与视觉/体力运动);后侧刺激加强了前侧双侧/注意力网络,并将FPN与DMN/视觉网络脱.
结论:
- 小脑积极调节皮质皮质功能连接.
- 特定的小脑区域具有不同的影响:后部中线针对DMN,而后侧小脑促进了任务准备的认知状态.
- 这些发现提供了关于小脑对皮质的影响的见解,对神经和精神疾病有潜在的临床应用.
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