预防性全胃切除术对遗传性扩散性胃癌的心理社会影响:叙述性综述
Olivia Kearns1, Deborah Snyder1, Jeremy Davis2
1Intramural Research Program at the National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Psycho-oncology
|October 23, 2025
概括
预防性全胃切除术 (PTG) 对CDH1变种的影响生活质量. 本次审查强调了综合心理健康护理的必要性,以应对手术后患者面临的心理社会挑战.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 心理学 心理学 心理学
背景情况:
- 致病性CDH1变种增加了早期发病的扩散性胃癌的风险.
- 预防性全胃切除术 (PTG) 建议用于CDH1变体携带者.
- PTG显著影响患者的生活质量 (QOL) 和心理健康.
研究的目的:
- 审查和总结在CDH1变体携带者中报告的PTG后的心理社会后果和QOL结果.
- 确定受PTG影响的关键心理社会领域.
- 为制定基于证据的患者护理建议提供信息.
主要方法:
- 在PubMed数据库的文献搜索中,使用与胃切除术,CDH1和心理结果相关的特定关键词.
- 包括专注于PTG或全胃切除术 (TG) 的心理和QOL影响的文章.
- 不包括缺乏关于心理社会因素的具体细节的文章.
主要成果:
- 37篇文章符合列入标准.
- 确定的主要心理社会领域包括QOL (22篇文章),社会关系 (12),抑郁和焦虑 (8),决策 (7),身体形象 (5),就业和财务 (4),和药物滥用 (3).
结论:
- 遗传性癌症综合征的诊断与PTG相结合,造成了显著的心理社会脆弱性.
- 显然需要在整个PTG外科连续过程中进行标准化的精神健康护理整合.
- 解决接受PTG的CDH1变异携带者的心理社会需求对于改善患者的治疗结果至关重要.
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