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丝启用符合规范的心室内接口,用于最小入侵的神经记录

Jizhi Liang^1,2, Xiner Wang^1,2, Zhaohan Chen³

¹2020 X-Lab, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, 200050, China.

Nature communications

|October 23, 2025

概括

研究人员开发了一种灵活的腹腔内接口 (IVI),用于监测深层大脑活动. 这种新型的神经接口成功地记录了帕金森症绵羊的脑信号,持续了四周,有助于神经电路研究.

科学领域:

神经科学是一个神经科学.
生物医学工程生物医学工程
医疗器械医疗器械

背景情况:

皮下神经活动监测对于理解大脑电路至关重要.
缺乏用于与大脑脊髓液内的皮下细胞核接口的转化工具.

研究的目的:

开发一款灵活且符合规格的静脉内膜接口 (IVI),用于最小侵入性的皮层下神经监测.
评估IVI记录神经信号的能力及其生物相容性.

主要方法:

开发了一种灵活,可变形的微电极阵列,与IVI的丝支架相集成.
使用临床导管将IVI最小侵入性植入侧腔室.
通过长期记录帕金森症母羊四周的信号质量和生物相容性进行评估.

主要成果:

该IVI自行展开并符合脑脊液内的周周神经结构.
由于机内微电极屏蔽,可以捕获高质量的神经信号.
在帕金森症羊群中,在四周内取得了稳定,生物相容的体内记录,检测出深层大脑异常.

结论:

该IVI平台能够对健康和疾病的大脑深部区域进行慢性监测和电路分析.
促进了神经回路的研究,连接周周结膜表面神经元与遥远的大脑区域.
代表了用于皮下神经接口研究的翻译工具的重大进步.

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