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Updated: Jan 14, 2026

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以结构为导向的奥托彼得林1抑制剂的发现揭示了在内亚单元界面的可药结合点

Batuujin Burendei1, Joshua P Kaplan2,3, Gerardo M Orellana2

  • 1Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.

Nature communications
|October 23, 2025
PubMed
概括

研究人员确定了小分子抑制剂的Otopetrins (OTOPs),质子选择性离子通道对于功能,如酸味感知至关重要. 这些抑制剂在低至中微米范围内有效,为研究OTOP通道活性和结构提供了新的工具.

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