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Updated: Jan 14, 2026

Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton
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Published on: April 19, 2018

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与关联的IV型原蛋白促进了C. elegans生殖系中GLP-1/Notch受体的激活

Pier-Olivier Martel1,2, Rustelle Janse van Vuuren1,2, Julia Degrémont3

  • 1Département de Biologie Médicale, Université du Québec à Trois-Rivières, Québec, Canada.

Nature communications
|October 23, 2025
PubMed
概括

纤维化,标志着IV型原蛋白 (COL IV) 的增加,促进老化组织中的Notch信号. 意想不到的是,减少Notch活动会加剧纤维化,这表明与衰老相关的纤维化可能通过增强Notch信号来驱动癌症.

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