通过基于环氧的包容复合物增强Limonium bellidifolium的生物活性和生物可用性:从基源发现药物的新策略
Güneş Ak1, Stefano Dall'Acqua2, Stefania Sut2
1Physiology and Biochemistry Research Laboratory, Department of Biology, Science Faculty, Selcuk University, Konya, 42130, Turkey. akguneselcuk@gmail.com.
Scientific reports
|October 23, 2025
概括
环德克斯特林封装显著提高了来自Limonium bellidifolium的植物化学品的溶解性,稳定性和生物可用性. 这种方法可以改善化合物保留,并增强治疗用途的抗氧化和酶抑制活性.
科学领域:
- 植物化学 植物化学
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 白是生物活性植物化学物质的植物来源,具有潜在的治疗益处.
- 植物化学物质通常具有不良的溶解性,稳定性和生物可用性,限制了它们的有效性.
- 环德林封装是一种有前途的技术,可以克服这些局限性.
研究的目的:
- 通过使用α-和β-环氧囊封装,研究提升Limonium bellidifolium植物化学品的可溶性,稳定性和生物可用性.
- 为了评估封装提取物在模拟体外胃肠道消化过程中的性能.
- 评估封装对植物化学品抗氧化剂和酶抑制活性的影响.
主要方法:
- 乙醇/水提取物Limonium bellidifolium被封装在不同的温度 (25°C,40°C,60°C) 的alpha-和beta-cyclodextrins.
- 模拟了体外胃肠道消化,以评估封装化合物的稳定性和恢复性.
- 福里埃变换红外光谱 (FTIR) 和扫描电子显微镜 (SEM) 用于结构分析.
- 评估了生物可用性,抗氧化活性 (DPPH测定) 和酶抑制 (铁酶,乙胆酶).
主要成果:
- 用β-cyclopodextrin在25°C和用α-cyclopodextrin在40°C时实现了最佳封装.
- FTIR和SEM证实了最小的化学变化和形成良好的封装颗粒.
- 封装样本显示主要化合物 (quercetin,catechin,ferulic acid) 的回收在消化后明显高于纯提取物.
- 封装形式表现出增强的抗氧化活性和显著的铁酶和乙胆酶抑制,特别是β-环德素封装的根提取物.
结论:
- 环德克斯封装有效地提高了Limonium bellidifolium植物化学品的可溶性,稳定性和生物可用性.
- 封装策略在消化过程中提供了显著的保护,增强了关键化合物的保留和生物活性.
- 这项研究提出了一种新且有效的方法,用于开发Limonium bellidifolium植物化学品,用于治疗和营养药物应用.
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