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相关概念视频

In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

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Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients,...
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In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

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Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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In Vitro Drug Release Testing: Overview, Development and Validation01:10

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In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
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相关实验视频

Updated: Jan 14, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
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可编程的分子脱线,以实现可调节的药物释放.

Shen Sheng1, Yuanhe Li2, Ryan Ray Yen Lee1

  • 1Department of Pharmacy and Pharmaceutical Sciences National University of Singapore 4 Science Drive 2, Singapore, Singapore.

Nature communications
|October 23, 2025
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概括
此摘要是机器生成的。

研究人员通过控制伪甲素脱线来设计分子机器. 这一突破使得可调节的分子运动成为可能,为可编程药物输送系统和先进的生物医学应用铺平了道路.

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科学领域:

  • 超分子化学 超分子化学
  • 材料科学 材料科学 材料科学
  • 纳米技术纳米技术

背景情况:

  • 精确控制分子运动对于开发人工分子机器至关重要.
  • 伪托克桑脱线是相互锁定的架构中调节分子运动的关键过程.
  • 对脱线动力学的可预测和可编程控制仍然是一个重大挑战.

研究的目的:

  • 通过组件工程来实现伪托克桑脱线行为的系统调节.
  • 建立结构-动力关系,规范脱线路.
  • 在药物输送应用中展示工程化伪素的潜力.

主要方法:

  • 采用了一种伪托克萨恩平台,具有24-皇冠-8基宏循环和可调节的基胺塞.
  • 执行系统的组件工程来调节脱线动力学.
  • 采用晶体分析和计算建模来阐明解线机制.
  • 功能化伪托克桑组合与抗癌药物坎普托西因用于概念验证研究.

主要成果:

  • 证明了激活能量的连续调整能力,用于在22到30kcal/mol的范围内进行脱线,具有很好的分辨率.
  • 使用晶体学和计算方法阐明了脱线路和结构动力学关系.
  • 在康普托素功能化伪素中,脱率和细胞毒性强度之间显示出一致的相关性.

结论:

  • 通过工程分子机器来设计可编程药物输送系统的可通用策略.
  • 通过受控的伪毒素脱线,将分子级机械运动与生物效应相结合.
  • 奠定了先进的分子机器的基础,在生物医学应用中使用新的伪托克桑工具包.